Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

Hyperpolarized [1‐(13)C] pyruvate MRS can measure cardiac pyruvate dehydrogenase (PDH) flux in vivo through (13)C‐label incorporation into bicarbonate. Using this technology, substrate availability as well as pathology have been shown to modulate PDH flux. Clinical protocols attempt to standardize P...

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Dades bibliogràfiques
Publicat a:NMR Biomed
Autors principals: Timm, Kerstin N., Apps, Andrew, Miller, Jack J., Ball, Vicky, Chong, Cher‐Rin, Dodd, Michael S., Tyler, Damian J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175301/
https://ncbi.nlm.nih.gov/pubmed/30040147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3992
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