Determining In Vivo Regulation of Cardiac Pyruvate Dehydrogenase Based on Label Flux from Hyperpolarized [1-(13)C]Pyruvate

BACKGROUND: Pyruvate dehydrogenase (PDH) is a key regulator of cardiac substrate selection and is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition. The extent to which chronic upregulation of PDK protein levels, acutely increased PDK activity and...

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Gepubliceerd in:NMR Biomed
Hoofdauteurs: Schroeder, Marie A., Atherton, Helen J., Heather, Lisa C., Griffin, Julian L., Clarke, Kieran, Radda, George K., Tyler, Damian J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604660/
https://ncbi.nlm.nih.gov/pubmed/21387444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.1668
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