Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease

BACKGROUND: In patients with autosomal dominant polycystic kidney disease (ADPKD), most of whom have a mutation in PKD1 or PKD2, abnormally large numbers of macrophages accumulate around kidney cysts and promote their growth. Research by us and others has suggested that monocyte chemoattractant prot...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Cassini, Marcelo F., Kakade, Vijayakumar R., Kurtz, Elizabeth, Sulkowski, Parker, Glazer, Peter, Torres, Richard, Somlo, Stefan, Cantley, Lloyd G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171277/
https://ncbi.nlm.nih.gov/pubmed/30209078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018050518
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