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Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport-related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivati...

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Hlavní autoři: Ma, Ming, Tian, Xin, Igarashi, Peter, Pazour, Gregory J., Somlo, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758452/
https://ncbi.nlm.nih.gov/pubmed/23892607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2715
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