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Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport-related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivati...

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Bibliografiske detaljer
Main Authors: Ma, Ming, Tian, Xin, Igarashi, Peter, Pazour, Gregory J., Somlo, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758452/
https://ncbi.nlm.nih.gov/pubmed/23892607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2715
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