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Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport-related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivati...

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Bibliographische Detailangaben
Hauptverfasser: Ma, Ming, Tian, Xin, Igarashi, Peter, Pazour, Gregory J., Somlo, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758452/
https://ncbi.nlm.nih.gov/pubmed/23892607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2715
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