Hepatitis A Virus Codon Usage: Implications for Translation Kinetics and Capsid Folding

Codon usage bias is universal to all genomes. Hepatitis A virus (HAV) codon usage is highly biased and deoptimized with respect to its host. Accordingly, HAV is unable to induce cellular translational shutoff and its internal ribosome entry site (IRES) is inefficient. Codon usage deoptimization may...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Med
Main Authors: Pintó, Rosa M., Pérez-Rodríguez, Francisco-Javier, D’Andrea, Lucia, de Castellarnau, Montserrat, Guix, Susana, Bosch, Albert
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169985/
https://ncbi.nlm.nih.gov/pubmed/29530949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031781
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