Hepatitis A Virus Codon Usage: Implications for Translation Kinetics and Capsid Folding

Codon usage bias is universal to all genomes. Hepatitis A virus (HAV) codon usage is highly biased and deoptimized with respect to its host. Accordingly, HAV is unable to induce cellular translational shutoff and its internal ribosome entry site (IRES) is inefficient. Codon usage deoptimization may...

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Bibliografiska uppgifter
I publikationen:Cold Spring Harb Perspect Med
Huvudupphovsmän: Pintó, Rosa M., Pérez-Rodríguez, Francisco-Javier, D’Andrea, Lucia, de Castellarnau, Montserrat, Guix, Susana, Bosch, Albert
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2018
Ämnen:
Perspectives
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169985/
https://ncbi.nlm.nih.gov/pubmed/29530949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031781
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