Hepatitis A Virus Codon Usage: Implications for Translation Kinetics and Capsid Folding

Codon usage bias is universal to all genomes. Hepatitis A virus (HAV) codon usage is highly biased and deoptimized with respect to its host. Accordingly, HAV is unable to induce cellular translational shutoff and its internal ribosome entry site (IRES) is inefficient. Codon usage deoptimization may...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Perspect Med
Main Authors: Pintó, Rosa M., Pérez-Rodríguez, Francisco-Javier, D’Andrea, Lucia, de Castellarnau, Montserrat, Guix, Susana, Bosch, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
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Perspectives
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169985/
https://ncbi.nlm.nih.gov/pubmed/29530949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031781
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