Advances for the Hepatitis A Virus Antigen Production Using a Virus Strain With Codon Frequency Optimization Adjustments in Specific Locations

The available cell-adapted hepatitis A virus (HAV) strains show a very slow replication phenotype hampering the affordable production of antigen. A fast-growing strain characterized by the occurrence of mutations in the internal ribosome entry site (IRES), combined with changes in the codon composit...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Microbiol
Auteurs principaux: Chavarria-Miró, Gemma, de Castellarnau, Montserrat, Fuentes, Cristina, D’Andrea, Lucía, Pérez-Rodríguez, Francisco-Javier, Beguiristain, Nerea, Bosch, Albert, Guix, Susana, Pintó, Rosa M.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935560/
https://ncbi.nlm.nih.gov/pubmed/33679679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2021.642267
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