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Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice

MET and epidermal growth factor receptor (EGFR) tyrosine kinases are crucial for liver regeneration and normal hepatocyte function. Recently, we demonstrated that in mice, combined inhibition of these two signaling pathways abolished liver regeneration after hepatectomy, with subsequent hepatic fail...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Tsagianni, Anastasia, Mars, Wendy M., Bhushan, Bharat, Bowen, William C., Orr, Anne, Stoops, John, Paranjpe, Shirish, Tseng, George C., Liu, Silvia, Michalopoulos, George K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168971/
https://ncbi.nlm.nih.gov/pubmed/30031724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.06.009
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