TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling

TCPOBOP (1,4-Bis [2-(3,5-Dichloropyridyloxy)] benzene) is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP-induced direct hyperplasia has been considered to be CAR-dependent with no evidenc...

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Bibliographic Details
Published in:Hepatology
Main Authors: Bhushan, Bharat, Stoops, John W., Mars, Wendy M., Orr, Anne, Bowen, William C., Paranjpe, Shirish, Michalopoulos, George K.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289897/
https://ncbi.nlm.nih.gov/pubmed/29888801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30109
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