Combined systemic elimination of MET and EGFR signaling completely abolishes liver regeneration and leads to liver decompensation

Receptor tyrosine kinases MET and EGFR are critically involved in initiation of liver regeneration. Other cytokines and signaling molecules also participate in the early part of the process. Regeneration employs effective redundancy schemes to compensate for the missing signals. Elimination of any s...

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Veröffentlicht in:Hepatology
Hauptverfasser: Paranjpe, Shirish, Bowen, William C., Mars, Wendy M., Orr, Anne, Haynes, Meagan M., DeFrances, Marie C., Liu, Silvia, Tseng, George C., Tsagianni, Anastasia, Michalopoulos, George K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074871/
https://ncbi.nlm.nih.gov/pubmed/27397846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28721
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