Combined systemic elimination of MET and EGFR signaling completely abolishes liver regeneration and leads to liver decompensation

Receptor tyrosine kinases MET and EGFR are critically involved in initiation of liver regeneration. Other cytokines and signaling molecules also participate in the early part of the process. Regeneration employs effective redundancy schemes to compensate for the missing signals. Elimination of any s...

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Publié dans:Hepatology
Auteurs principaux: Paranjpe, Shirish, Bowen, William C., Mars, Wendy M., Orr, Anne, Haynes, Meagan M., DeFrances, Marie C., Liu, Silvia, Tseng, George C., Tsagianni, Anastasia, Michalopoulos, George K.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074871/
https://ncbi.nlm.nih.gov/pubmed/27397846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28721
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