Yes‐Associated Protein Is Crucial for Constitutive Androstane Receptor‐Driven Hepatocyte Proliferation But Not for Induction of Drug Metabolism Genes in Mice

BACKGROUND AND AIMS: Constitutive androstane receptor (CAR) agonists, such as 1,4‐bis [2‐(3,5‐dichloropyridyloxy)] benzene (TCPOBOP), are known to cause robust hepatocyte proliferation and hepatomegaly in mice along with induction of drug metabolism genes without any associated liver injury. Yes‐ass...

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Vydáno v:Hepatology
Hlavní autoři: Bhushan, Bharat, Molina, Laura, Koral, Kelly, Stoops, John W., Mars, Wendy M., Banerjee, Swati, Orr, Anne, Paranjpe, Shirish, Monga, Satdarshan P., Locker, Joseph, Michalopoulos, George K.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885729/
https://ncbi.nlm.nih.gov/pubmed/32794202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31521
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