Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathways targeted by Notch signaling and the precise ligand and receptor pair that are responsible for kidney disease remain poorly defined. In this study, we found that JAG1 and NOTCH2 showed the strongest...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Huang, Shizheng, Park, Jihwan, Qiu, Chengxiang, Chung, Ki Wung, Li, Szu-yuan, Sirin, Yasemin, Han, Seung Hyeok, Taylor, Verdon, Zimber-Strobl, Ursula, Susztak, Katalin
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161902/
https://ncbi.nlm.nih.gov/pubmed/30226866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005233
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