Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathways targeted by Notch signaling and the precise ligand and receptor pair that are responsible for kidney disease remain poorly defined. In this study, we found that JAG1 and NOTCH2 showed the strongest...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Huang, Shizheng, Park, Jihwan, Qiu, Chengxiang, Chung, Ki Wung, Li, Szu-yuan, Sirin, Yasemin, Han, Seung Hyeok, Taylor, Verdon, Zimber-Strobl, Ursula, Susztak, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161902/
https://ncbi.nlm.nih.gov/pubmed/30226866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005233
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