Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

While Notch signaling has been proposed to play a key role in fibrosis, the direct molecular pathways targeted by Notch signaling and the precise ligand and receptor pair that are responsible for kidney disease remain poorly defined. In this study, we found that JAG1 and NOTCH2 showed the strongest...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Biol
Hauptverfasser: Huang, Shizheng, Park, Jihwan, Qiu, Chengxiang, Chung, Ki Wung, Li, Szu-yuan, Sirin, Yasemin, Han, Seung Hyeok, Taylor, Verdon, Zimber-Strobl, Ursula, Susztak, Katalin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161902/
https://ncbi.nlm.nih.gov/pubmed/30226866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005233
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