Mitochondrial damage and activation of the STING pathway leads to renal inflammation and fibrosis

Fibrosis of the kidney is the final common pathway leading to end stage renal failure. By analyzing kidneys of patients and animal models with fibrosis we observed a significant mitochondrial defect, including the loss of the mitochondrial transcription factor A (TFAM) in kidney tubule cells. Here,...

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Bibliografiska uppgifter
I publikationen:Cell Metab
Huvudupphovsmän: Chung, Ki Wung, Dhillon, Poonam, Huang, Shizheng, Sheng, Xin, Shrestha, Rojesh, Qiu, Chengxiang, Kaufman, Brett A., Park, Jihwan, Pei, Liming, Baur, Joseph, Palmer, Matthew, Susztak, Katalin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054893/
https://ncbi.nlm.nih.gov/pubmed/31474566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.08.003
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