Mitochondrial damage and activation of the STING pathway leads to renal inflammation and fibrosis

Fibrosis of the kidney is the final common pathway leading to end stage renal failure. By analyzing kidneys of patients and animal models with fibrosis we observed a significant mitochondrial defect, including the loss of the mitochondrial transcription factor A (TFAM) in kidney tubule cells. Here,...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Chung, Ki Wung, Dhillon, Poonam, Huang, Shizheng, Sheng, Xin, Shrestha, Rojesh, Qiu, Chengxiang, Kaufman, Brett A., Park, Jihwan, Pei, Liming, Baur, Joseph, Palmer, Matthew, Susztak, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054893/
https://ncbi.nlm.nih.gov/pubmed/31474566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.08.003
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