Mitochondrial damage and activation of the STING pathway leads to renal inflammation and fibrosis

Fibrosis of the kidney is the final common pathway leading to end stage renal failure. By analyzing kidneys of patients and animal models with fibrosis we observed a significant mitochondrial defect, including the loss of the mitochondrial transcription factor A (TFAM) in kidney tubule cells. Here,...

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Publicado en:Cell Metab
Autores principales: Chung, Ki Wung, Dhillon, Poonam, Huang, Shizheng, Sheng, Xin, Shrestha, Rojesh, Qiu, Chengxiang, Kaufman, Brett A., Park, Jihwan, Pei, Liming, Baur, Joseph, Palmer, Matthew, Susztak, Katalin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054893/
https://ncbi.nlm.nih.gov/pubmed/31474566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.08.003
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