Mitochondrial damage and activation of the STING pathway leads to renal inflammation and fibrosis

Fibrosis of the kidney is the final common pathway leading to end stage renal failure. By analyzing kidneys of patients and animal models with fibrosis we observed a significant mitochondrial defect, including the loss of the mitochondrial transcription factor A (TFAM) in kidney tubule cells. Here,...

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Bibliografski detalji
Izdano u:Cell Metab
Glavni autori: Chung, Ki Wung, Dhillon, Poonam, Huang, Shizheng, Sheng, Xin, Shrestha, Rojesh, Qiu, Chengxiang, Kaufman, Brett A., Park, Jihwan, Pei, Liming, Baur, Joseph, Palmer, Matthew, Susztak, Katalin
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054893/
https://ncbi.nlm.nih.gov/pubmed/31474566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.08.003
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