PGC-1α Protects from Notch-Induced Kidney Fibrosis Development

Kidney fibrosis is the histologic manifestation of CKD. Sustained activation of developmental pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in fibrosis development. The molecular mechanism of Notch-induced fibrosis, however, remains poorly understood. Here, we...

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Podrobná bibliografie
Vydáno v:J Am Soc Nephrol
Hlavní autoři: Han, Seung Hyeok, Wu, Mei-yan, Nam, Bo Young, Park, Jung Tak, Yoo, Tae-Hyun, Kang, Shin-Wook, Park, Jihwan, Chinga, Frank, Li, Szu-Yuan, Susztak, Katalin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2017
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661291/
https://ncbi.nlm.nih.gov/pubmed/28751525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017020130
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