Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy

Inherited and acquired mitochondrial defects have been associated with podocyte dysfunction and chronic kidney disease (CKD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α) is one of the main transcriptional regulators of mitochondrial biogenesis and function. We hypothesized th...

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Udgivet i:JCI Insight
Main Authors: Li, Szu-Yuan, Park, Jihwan, Qiu, Chengxiang, Han, Seung Hyeok, Palmer, Matthew B., Arany, Zoltan, Susztak, Katalin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518556/
https://ncbi.nlm.nih.gov/pubmed/28724797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92930
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