Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing

The abundant RNA modification pseudouridine (Ψ) has been mapped transcriptome-wide by chemically modifying pseudouridines with carbodiimide and detecting the resulting reverse transcription stops in high-throughput sequencing. However, these methods have limited sensitivity and specificity, in part...

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Bibliografiske detaljer
Udgivet i:RNA Biol
Main Authors: Zhou, Katherine I., Clark, Wesley C., Pan, David W., Eckwahl, Matthew J., Dai, Qing, Pan, Tao
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Technical Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161689/
https://ncbi.nlm.nih.gov/pubmed/29683381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1462654
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