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Sensitive and quantitative probing of pseudouridine modification in mRNA and long noncoding RNA

Pseudouridine (Ψ) is the most abundant RNA modification in cellular RNA present in tRNA/rRNA/snRNA and also in mRNA and long noncoding RNA (lncRNA). Elucidation of Ψ function in mRNA/lncRNA requires mapping and quantitative assessment of its modification fraction at single-base resolution. The most...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Zhang, Wen, Eckwahl, Matthew J., Zhou, Katherine I., Pan, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800517/
https://ncbi.nlm.nih.gov/pubmed/31227565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072124.119
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