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Pseudouridine-mediated stop codon readthrough in S. cerevisiae is sequence context–independent

We have previously shown that when the uridine of a stop codon (UAA, UAG, or UGA) is pseudouridylated, the ribosome reads through the modified stop codon. However, it is not clear as to whether or not the pseudouridine (Ψ)-mediated readthrough is dependent on the sequence context of mRNA. Here, we u...

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Vydáno v:RNA
Hlavní autoři: Adachi, Hironori, Yu, Yi-Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430670/
https://ncbi.nlm.nih.gov/pubmed/32434780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.076042.120
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