Silencing Carboxylesterase 1 in Human THP-1 Macrophages Perturbs Genes Regulated by PPARγ/RXR and RAR/RXR: Downregulation of CYP27A1-LXRα Signaling

Macrophage foam cells store excess cholesterol as cholesteryl esters, which need to be hydrolyzed for cholesterol efflux. We recently reported that silencing expression of carboxylesterase 1 (CES1) in human THP-1 macrophages (CES1KD macrophages) reduced cholesterol uptake and decreased expression of...

Full description

Saved in:
Bibliographic Details
Published in:Biochem J
Main Authors: Mangum, Lee C., Hou, Xiang, Borazjani, Abdolsamad, Lee, Jung Hwa, Ross, Matthew K., Crow, J. Allen
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159944/
https://ncbi.nlm.nih.gov/pubmed/29321244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180008
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items