Effects of Toxicologically Relevant Xenobiotics and the Lipid-Derived Electrophile 4-Hydroxynonenal on Macrophage Cholesterol Efflux: Silencing Carboxylesterase 1 Has Paradoxical Effects on Cholesterol Uptake and Efflux

[Image: see text] Cholesterol cycles between free cholesterol (unesterified) found predominantly in membranes and cholesteryl esters (CEs) stored in cytoplasmic lipid droplets. Only free cholesterol is effluxed from macrophages via ATP-binding cassette (ABC) transporters to extracellular acceptors....

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Main Authors: Ross, Matthew K., Borazjani, Abdolsamad, Mangum, Lee C., Wang, Ran, Crow, J. Allen
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203386/
https://ncbi.nlm.nih.gov/pubmed/25250848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500221a
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