Silencing Carboxylesterase 1 in Human THP-1 Macrophages Perturbs Genes Regulated by PPARγ/RXR and RAR/RXR: Downregulation of CYP27A1-LXRα Signaling

Macrophage foam cells store excess cholesterol as cholesteryl esters, which need to be hydrolyzed for cholesterol efflux. We recently reported that silencing expression of carboxylesterase 1 (CES1) in human THP-1 macrophages (CES1KD macrophages) reduced cholesterol uptake and decreased expression of...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Mangum, Lee C., Hou, Xiang, Borazjani, Abdolsamad, Lee, Jung Hwa, Ross, Matthew K., Crow, J. Allen
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159944/
https://ncbi.nlm.nih.gov/pubmed/29321244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180008
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