Silencing Carboxylesterase 1 in Human THP-1 Macrophages Perturbs Genes Regulated by PPARγ/RXR and RAR/RXR: Downregulation of CYP27A1-LXRα Signaling

Macrophage foam cells store excess cholesterol as cholesteryl esters, which need to be hydrolyzed for cholesterol efflux. We recently reported that silencing expression of carboxylesterase 1 (CES1) in human THP-1 macrophages (CES1KD macrophages) reduced cholesterol uptake and decreased expression of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Mangum, Lee C., Hou, Xiang, Borazjani, Abdolsamad, Lee, Jung Hwa, Ross, Matthew K., Crow, J. Allen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159944/
https://ncbi.nlm.nih.gov/pubmed/29321244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados