Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids

Mutations of mitochondrial transfer RNAs (mt-tRNAs) play a major role in a wide range of mitochondrial diseases because of the vital role of these molecules in mitochondrial translation. It has previously been reported that the overexpression of mitochondrial aminoacyl tRNA synthetases is effective...

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Udgivet i:Int J Biol Sci
Main Authors: Zhao, Xiaoxu, Han, Jiamin, Zhu, Ling, Xiao, Yun, Wang, Chenghui, Hong, Fang, Jiang, Pingping, Guan, Min-Xin
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158735/
https://ncbi.nlm.nih.gov/pubmed/30262995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.27043
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