Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids

Mutations of mitochondrial transfer RNAs (mt-tRNAs) play a major role in a wide range of mitochondrial diseases because of the vital role of these molecules in mitochondrial translation. It has previously been reported that the overexpression of mitochondrial aminoacyl tRNA synthetases is effective...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Zhao, Xiaoxu, Han, Jiamin, Zhu, Ling, Xiao, Yun, Wang, Chenghui, Hong, Fang, Jiang, Pingping, Guan, Min-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158735/
https://ncbi.nlm.nih.gov/pubmed/30262995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.27043
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