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Principles of tRNA(Ala) Selection by Alanyl–tRNA Synthetase Based on the Critical G3·U70 Base Pair

[Image: see text] Throughout evolution, the presence of a single G3·U70 mismatch in the acceptor stem of tRNA(Ala) is the major determinant for aminoacylation with alanine by alanyl–tRNA synthetase (AlaRS). Recently reported crystal structures of the complexes AlaRS–tRNA(Ala)/G3·U70 and AlaRS–tRNA(A...

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Publicat a:ACS Omega
Autors principals: Kumar, Amit, Åqvist, Johan, Satpati, Priyadarshi
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761608/
https://ncbi.nlm.nih.gov/pubmed/31572855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01827
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