Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids

Mutations of mitochondrial transfer RNAs (mt-tRNAs) play a major role in a wide range of mitochondrial diseases because of the vital role of these molecules in mitochondrial translation. It has previously been reported that the overexpression of mitochondrial aminoacyl tRNA synthetases is effective...

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Publicado en:Int J Biol Sci
Autores principales: Zhao, Xiaoxu, Han, Jiamin, Zhu, Ling, Xiao, Yun, Wang, Chenghui, Hong, Fang, Jiang, Pingping, Guan, Min-Xin
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158735/
https://ncbi.nlm.nih.gov/pubmed/30262995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.27043
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