Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids

Mutations of mitochondrial transfer RNAs (mt-tRNAs) play a major role in a wide range of mitochondrial diseases because of the vital role of these molecules in mitochondrial translation. It has previously been reported that the overexpression of mitochondrial aminoacyl tRNA synthetases is effective...

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Gepubliceerd in:Int J Biol Sci
Hoofdauteurs: Zhao, Xiaoxu, Han, Jiamin, Zhu, Ling, Xiao, Yun, Wang, Chenghui, Hong, Fang, Jiang, Pingping, Guan, Min-Xin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ivyspring International Publisher 2018
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158735/
https://ncbi.nlm.nih.gov/pubmed/30262995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.27043
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