Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

The platelet receptors glycoprotein Ibα (GPIbα) and GPVI are known to be cleaved by members of a disintegrin and metalloprotease (ADAM) family (ADAM10 and ADAM17), but the mechanisms and consequences of this shedding are not well understood. Our results revealed that (1) glycoprotein shedding is con...

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Udgivet i:Blood Adv
Main Authors: Baaten, Constance C. F. M. J., Swieringa, Frauke, Misztal, Tomasz, Mastenbroek, Tom G., Feijge, Marion A. H., Bock, Paul E., Donners, Marjo M. P. C., Collins, Peter W., Li, Renhao, van der Meijden, Paola E. J., Heemskerk, Johan W. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156892/
https://ncbi.nlm.nih.gov/pubmed/30232085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017011544
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