ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

The mechanistic target of rapamycin (mTOR) serine/threonine kinase, a critical regulator of cell proliferation, is frequently deregulated in human cancer. Although rapamycin inhibits the two canonical mTOR complexes, mTORC1 and mTORC2, it often shows minimal benefit as an anticancer drug. This is ca...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Harwood, Franklin C., Klein Geltink, Ramon I., O’Hara, Brendan P., Cardone, Monica, Janke, Laura, Finkelstein, David, Entin, Igor, Paul, Leena, Houghton, Peter J., Grosveld, Gerard C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156121/
https://ncbi.nlm.nih.gov/pubmed/30258985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar3938
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