ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

The mechanistic target of rapamycin (mTOR) serine/threonine kinase, a critical regulator of cell proliferation, is frequently deregulated in human cancer. Although rapamycin inhibits the two canonical mTOR complexes, mTORC1 and mTORC2, it often shows minimal benefit as an anticancer drug. This is ca...

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Publicado en:Sci Adv
Autores principales: Harwood, Franklin C., Klein Geltink, Ramon I., O’Hara, Brendan P., Cardone, Monica, Janke, Laura, Finkelstein, David, Entin, Igor, Paul, Leena, Houghton, Peter J., Grosveld, Gerard C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156121/
https://ncbi.nlm.nih.gov/pubmed/30258985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar3938
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