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Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that increases this activity. These studies demonstrate...
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| Vydáno v: | Mol Cell Oncol |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6154841/ https://ncbi.nlm.nih.gov/pubmed/30263937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1432259 |
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