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Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney

Activation-induced DNA cytosine deaminase (AID) is required for somatic hypermutation (SHM) and efficient class switch recombination (CSR) of immunoglobulin (Ig) genes. We created AID-transgenic mice that express AID ubiquitously under the control of a β–actin promoter. When crossed with AID−/− mice...

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Detalhes bibliográficos
Main Authors: Shen, Hong Ming, Bozek, Grazyna, Pinkert, Carl A., McBride, Kevin, Wang, Lilly, Kenter, Amy, Storb, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376253/
https://ncbi.nlm.nih.gov/pubmed/18067961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2007.10.041
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