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Somatic hypermutation of the AID transgene in B and non-B cells

Somatic hypermutation (SHM) of the Ig genes is required for affinity maturation of the humoral response to foreign antigens. Activation-induced cytidine deaminase (AID), which is specifically expressed in germinal center centroblasts, is indispensable for this process. Expression of AID is sufficien...

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Detalhes bibliográficos
Main Authors: Martin, Alberto, Scharff, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC129440/
https://ncbi.nlm.nih.gov/pubmed/12202747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192442899
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