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Somatic hypermutation of the AID transgene in B and non-B cells
Somatic hypermutation (SHM) of the Ig genes is required for affinity maturation of the humoral response to foreign antigens. Activation-induced cytidine deaminase (AID), which is specifically expressed in germinal center centroblasts, is indispensable for this process. Expression of AID is sufficien...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2002
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129440/ https://ncbi.nlm.nih.gov/pubmed/12202747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192442899 |
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