The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

IntoductionTwo scaffold/matrix attachment regions (5’- and 3’-MARsEµ) flank the intronic core enhancer (cEµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARsEµ is still unclear and their involvement in somatic hypermutat...

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Detalhes bibliográficos

Principais autores:	Ophélie A. Martin, Morgane Thomas, Marie Marquet, Charlotte Bruzeau, Armand Garot, Mylène Brousse, Sébastien Bender, Claire Carrion, Jee Eun Choi, Bao Q. Vuong, Patricia J. Gearhart, Robert W. Maul, Sandrine Le Noir, Eric Pinaud
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-02-01
coleção:	Frontiers in Immunology
Assuntos:	B cell immunoglobulin gene MARs region somatic hypermutation (SHM) UNG
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1030813/full
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