No Overt Clinical Immunodeficiency Despite Immune Biological Abnormalities in Patients With Constitutional Mismatch Repair Deficiency

Immunoglobulin class-switch recombination (CSR) and somatic hypermutations (SHMs) are prerequisites for antibody and immunoglobulin receptor maturation and adaptive immune diversity. The mismatch repair (MMR) machinery, consisting of homologs of MutSα, MutLα, and MutSβ (MSH2/MSH6, MLH1/PMS2, and MSH...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Victoria K. Tesch, Hanna IJspeert, Andrea Raicht, Daniel Rueda, Nerea Dominguez-Pinilla, Luis M. Allende, Chrystelle Colas, Thorsten Rosenbaum, Denisa Ilencikova, Hagit N. Baris, Michaela H. M. Nathrath, Manon Suerink, Danuta Januszkiewicz-Lewandowska, Iman Ragab, Amedeo A. Azizi, Soeren S. Wenzel, Johannes Zschocke, Wolfgang Schwinger, Matthias Kloor, Claudia Blattmann, Laurence Brugieres, Mirjam van der Burg, Katharina Wimmer, Markus G. Seidel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-07-01
Colecção:	Frontiers in Immunology
Assuntos:	primary immunodeficiency hyper-IgM syndrome DNA repair defect mismatch repair somatic hypermutation class-switch recombination
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01506/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!