Somatic hypermutation of the AID transgene in B and non-B cells
Somatic hypermutation (SHM) of the Ig genes is required for affinity maturation of the humoral response to foreign antigens. Activation-induced cytidine deaminase (AID), which is specifically expressed in germinal center centroblasts, is indispensable for this process. Expression of AID is sufficien...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129440/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12202747/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192442899 |
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