Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors()

The phosphoinositide 3-kinase–related kinase ATR is a central regulator of the DNA damage response. Its chemical inhibition eliminates subsets of cancer cells in various tumor types. This effect is caused at least partly by the synthetically lethal relationship between ATR and certain DNA repair gen...

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Pubblicato in:Neoplasia
Autori principali: Job, Albert, Schmitt, Lisa-Maria, von Wenserski, Lisa, Lankat-Buttgereit, Brigitte, Gress, Thomas M., Buchholz, Malte, Gallmeier, Eike
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2018
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154763/
https://ncbi.nlm.nih.gov/pubmed/30257222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.08.009
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