Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors()

The phosphoinositide 3-kinase–related kinase ATR is a central regulator of the DNA damage response. Its chemical inhibition eliminates subsets of cancer cells in various tumor types. This effect is caused at least partly by the synthetically lethal relationship between ATR and certain DNA repair gen...

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Detaylı Bibliyografya
Yayımlandı:Neoplasia
Asıl Yazarlar: Job, Albert, Schmitt, Lisa-Maria, von Wenserski, Lisa, Lankat-Buttgereit, Brigitte, Gress, Thomas M., Buchholz, Malte, Gallmeier, Eike
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2018
Konular:
Original article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154763/
https://ncbi.nlm.nih.gov/pubmed/30257222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.08.009
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