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Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents
A series of acyclic selenopurine nucleosides 3a–f and 4a–g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC(50...
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| Publicado en: | Molecules |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6152377/ https://ncbi.nlm.nih.gov/pubmed/28704950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22071167 |
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