Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents

A series of acyclic selenopurine nucleosides 3a–f and 4a–g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC(50...

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Bibliographic Details
Published in:	Molecules
Main Authors:	Sahu, Pramod K., Umme, Tamima, Yu, Jinha, Kim, Gyudong, Qu, Shuhao, Naik, Siddhi D., Jeong, Lak Shin
Format:	Artigo
Language:	Inglês
Published:	MDPI 2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6152377/ https://ncbi.nlm.nih.gov/pubmed/28704950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22071167
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Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents

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