Synthesis and antiviral activities of new acyclic and “double-headed” nucleoside analogues

To develop an understanding of the structure-activity relationships for the inhibition of orthopoxviruses by nucleoside analogues, a variety of novel chemical entities were synthesized. These included a series of pyrimidine 5-hypermodified acyclic nucleoside analogues based upon recently discovered...

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Gepubliceerd in:Bioorg Chem
Hoofdauteurs: Zhang, Xinying, Amer, Adel, Fan, Xuesen, Balzarini, Jan, Neyts, Johan, De Clercq, Erik, Prichard, Mark, Kern, Earl, Torrence, Paul F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2006
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265801/
https://ncbi.nlm.nih.gov/pubmed/17270235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2006.11.003
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