Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities

Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The act...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Ying, C., Holý, A., Hocková, D., Havlas, Z., De Clercq, E., Neyts, J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2005
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549220/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15728921/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.3.1177-1180.2005
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