Safety and tolerability of HIV-1 multiantigen pDNA vaccine given with IL-12 plasmid DNA via electroporation, boosted with a recombinant vesicular stomatitis virus HIV Gag vaccine in healthy volunteers in a randomized, controlled clinical trial

BACKGROUND: The addition of plasmid cytokine adjuvants, electroporation, and live attenuated viral vectors may further optimize immune responses to DNA vaccines in heterologous prime-boost combinations. The objective of this study was to test the safety and tolerability of a novel prime-boost vaccin...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Elizaga, Marnie L., Li, Shuying S., Kochar, Nidhi K., Wilson, Gregory J., Allen, Mary A., Tieu, Hong Van N., Frank, Ian, Sobieszczyk, Magdalena E., Cohen, Kristen W., Sanchez, Brittany, Latham, Theresa E., Clarke, David K., Egan, Michael A., Eldridge, John H., Hannaman, Drew, Xu, Rong, Ota-Setlik, Ayuko, McElrath, M. Juliana, Hay, Christine Mhorag
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147413/
https://ncbi.nlm.nih.gov/pubmed/30235286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202753
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