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Safety and tolerability of HIV-1 multiantigen pDNA vaccine given with IL-12 plasmid DNA via electroporation, boosted with a recombinant vesicular stomatitis virus HIV Gag vaccine in healthy volunteers in a randomized, controlled clinical trial

BACKGROUND: The addition of plasmid cytokine adjuvants, electroporation, and live attenuated viral vectors may further optimize immune responses to DNA vaccines in heterologous prime-boost combinations. The objective of this study was to test the safety and tolerability of a novel prime-boost vaccin...

詳細記述

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書誌詳細
出版年:PLoS One
主要な著者: Elizaga, Marnie L., Li, Shuying S., Kochar, Nidhi K., Wilson, Gregory J., Allen, Mary A., Tieu, Hong Van N., Frank, Ian, Sobieszczyk, Magdalena E., Cohen, Kristen W., Sanchez, Brittany, Latham, Theresa E., Clarke, David K., Egan, Michael A., Eldridge, John H., Hannaman, Drew, Xu, Rong, Ota-Setlik, Ayuko, McElrath, M. Juliana, Hay, Christine Mhorag
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147413/
https://ncbi.nlm.nih.gov/pubmed/30235286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202753
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