NCX-Mediated Subcellular Ca(2+) Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes

Long QT syndrome type 2 (LQT2) is a congenital disease characterized by loss of function mutations in hERG potassium channels (I(Kr)). LQT2 is associated with fatal ventricular arrhythmias promoted by triggered activity in the form of early afterdepolarizations (EADs). We previously demonstrated tha...

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Dades bibliogràfiques
Publicat a:Biophys J
Autors principals: Zhong, Mingwang, Rees, Colin M., Terentyev, Dmitry, Choi, Bum-Rak, Koren, Gideon, Karma, Alain
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
Matèries:
Channels and Transporters
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140381/
https://ncbi.nlm.nih.gov/pubmed/30173888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.004
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