New paradigm for drug therapies of cardiac fibrillation

by Karma, Alain
Published 2000

Turing instability mediated by voltage and calcium diffusion in paced cardiac cells

by Shiferaw, Yohannes, Karma, Alain
Published 2006

Spatiotemporal intracellular calcium dynamics during cardiac alternans

by Restrepo, Juan G., Karma, Alain
Published 2009

Coupled dynamics of voltage and calcium in paced cardiac cells

by Shiferaw, Yohannes, Sato, Daisuke, Karma, Alain
Published in Phys Rev E Stat Nonlin Soft Matter Phys (2005)

Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes

by Song, Zhen, Qu, Zhilin, Karma, Alain
Published in Proc Natl Acad Sci U S A (2017)

Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans

by Restrepo, Juan G., Weiss, James N., Karma, Alain
Published 2008

Spatiotemporal Dynamics of Calcium-Driven Cardiac Alternans

by Skardal, Per Sebastian, Karma, Alain, Restrepo, Juan G.
Published in Phys Rev E Stat Nonlin Soft Matter Phys (2014)

Calsequestrin-Mediated Mechanism for Cellular Calcium Transient Alternans

by Restrepo, Juan G., Weiss, James N., Karma, Alain
Published in Biophys J (2018)

Long-Lasting Sparks: Multi-Metastability and Release Competition in the Calcium Release Unit Network

by Song, Zhen, Karma, Alain, Weiss, James N., Qu, Zhilin
Published in PLoS Comput Biol (2016)

Topology-generating interfacial pattern formation during liquid metal dealloying

by Geslin, Pierre-Antoine, McCue, Ian, Gaskey, Bernard, Erlebacher, Jonah, Karma, Alain
Published in Nat Commun (2015)

Inferring the Cellular Origin of Voltage and Calcium Alternans from the Spatial Scales of Phase Reversal during Discordant Alternans

by Sato, Daisuke, Shiferaw, Yohannes, Qu, Zhilin, Garfinkel, Alan, Weiss, James N., Karma, Alain
Published 2007

New experimental evidence for mechanism of arrhythmogenic membrane potential alternans based on balance of electrogenic I(NCX) / I(Ca) currents

by Wan, Xiaoping, Cutler, Michael, Song, Zhen, Karma, Alain, Matsuda, Toshio, Baba, Akemichi, Rosenbaum, David S.
Published 2012

NCX-Mediated Subcellular Ca(2+) Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes

by Zhong, Mingwang, Rees, Colin M., Terentyev, Dmitry, Choi, Bum-Rak, Koren, Gideon, Karma, Alain
Published in Biophys J (2018)

The Ca(2+) transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

by Rees, Colin M, Yang, Jun-Hai, Santolini, Marc, Lusis, Aldons J, Weiss, James N, Karma, Alain
Published in eLife (2018)

Control of Electrical Alternans in Canine Cardiac Purkinje Fibers

by Christini, David J., Riccio, Mark L., Culianu, Calin A., Fox, Jeffrey J., Karma, Alain, Gilmour, Robert F.
Published 2006

Off-site control of repolarization alternans in cardiac fibers

by Krogh-Madsen, Trine, Karma, Alain, Riccio, Mark L., Jordan, Peter N., Christini, David J., Gilmour, Robert F.
Published 2010

Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome

by Ziv, Ohad, Morales, Eduardo, Song, Yoon-kyu, Peng, Xuwen, Odening, Katja E, Buxton, Alfred E, Karma, Alain, Koren, Gideon, Choi, Bum-Rak
Published 2009

Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice

by Rau, Christoph D., Romay, Milagros C., Tuteryan, Mary, Wang, Jessica J.-C., Santolini, Marc, Ren, Shuxun, Karma, Alain, Weiss, James N., Wang, Yibin, Lusis, Aldons J.
Published in Cell Syst (2016)

Transient Outward K+ Current (I(to)) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 1

by Choi, Bum-Rak, Li, Weiyan, Terentyev, Dmitry, Kabakov, Anatoli Y., Zhong, Mingwang, Rees, Colin M, Terentyeva, Radmila, Kim, Tae Yun, Qu, Zhilin, Peng, Xuwen, Karma, Alain, Koren, Gideon
Published in Circ Arrhythm Electrophysiol (2018)

A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure

by Santolini, Marc, Romay, Milagros C., Yukhtman, Clara L., Rau, Christoph D., Ren, Shuxun, Saucerman, Jeffrey J., Wang, Jessica J., Weiss, James N., Wang, Yibin, Lusis, Aldons J., Karma, Alain
Published in NPJ Syst Biol Appl (2018)